US: Synthetic Biology Research Helps Develop Advanced Biofuels

An important goal of synthetic biology is to produce valuable chemical products in a sustainable manner using simple, inexpensive, renewable raw materials. Computer-aided models and simulations similar to those developed by JBEI are one of the basic conditions for synthetic biology to achieve its goals. But so far, this biological tool is still limited.

Researchers at the United States Department of Energy's Institute for Joint Biology (JBEI) have shown that advances in computer-aided design of RNA molecular engineering systems may lead to breakthroughs in a range of industries, including the development of cheaper advanced biofuels. Scientists will use these new "RNA devices" to regulate gene expression in microbial cells, which will help scientists develop new E. coli strains. This strain can better digest switchgrass biomass and convert sugar into three transportation fuels: gasoline, diesel and jet fuel.

Breakthroughs in E. coli design have helped to use switchgrass and other non-edible biomass plants to produce cheaper advanced biofuels that can replace gasoline. JBEI's research focuses on the development of advanced biofuels, but researchers believe that their research concept may help other researchers develop other demand products, including biodegradable plastics and drugs for treatment.

The biological system is extremely complex, which makes it difficult for the microbiological engineering system to produce the desired amount of demand product. For the first time, the study established and adjusted the RNA system in a predictable way. It is worth mentioning that researchers are concerned with RNA sequence design methods that can be folded into complex three-dimensional images: ribozymes and aptamers. Using computer-aided modeling and simulations created by JBEI, researchers developed a sophisticated RNA-based control system that can plan for a large number of genes. In microbes, instructions are delivered to cells and processed through an RNA-based control system that helps form the desired product.

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