At present, metal-inert biomaterials such as stainless steel, cobalt alloys, metallic titanium, or titanium alloys are widely used for the replacement of body parts such as hips, bone chips, and dental implants after abrasion, disease, and injury. Due to the biological inertness of the metal graft material, the hydroxyapatite coating material system prepared on the surface of the metal material has been successfully applied in clinical skeletal surgery to promote rapid connection with the host bone tissue, but the long-term serviceability of the material is still a great deal. Issues of concern, especially the problem of brittleness of hydroxyapatite. The development of a novel inert metal/hydroxyapatite-based composite system with excellent biological and mechanical properties and the search for a novel material preparation method are of great interest to the biomaterials community.

Recently, Li Hua research team of Surface Technology Division of Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences successfully prepared a biomedical hydroxyapatite coating on a titanium alloy substrate by vacuum cold spraying at room temperature. The coating has obvious optimized mechanics. And biological properties. The results were completed by Li Hua, Liu Jing, Huang Jing, Li Hua and the thermal spraying team of Xi'an Jiaotong University and published in the journal Carbon (67 2014 250-259).

Li Hua's research on biomaterials in the team focused on the development of novel biomaterials and the study of biomaterial/cell interface behavior. The team has a liquid-phase co-precipitation method for the preparation of hydroxyapatite-graphene nanocomposite powder technology (Patent No. 201310409001.7) and adopts a vacuum cold spray technique to control thickness on inert metals, achieve excellent bonding strength of the film base, and optimize fracture toughness. Ceramic coating.

Microstructure characterization indicates that the technique completely transplants the physical properties of the powder into the coating without grain growth and phase changes. In vitro cell experiments demonstrated that the filopodia of osteoblasts have a tendency to extend and rivet to the graphene sheets. Further electron microscopy observations using negative staining techniques show that fibronectin on the surface of graphene has a rapid attachment of approximately 100-135 nm. This phenomenon explains why the graphene-coated hydroxyapatite coating promotes osteoblast spreading and subsequent proliferation. The novel nano-hydroxyapatite-graphene composite coating prepared by vacuum cold spraying provides more possibilities for the replacement and repair of human hard tissues.

This study was supported by the National Natural Science Foundation of China (project approval No. 31271017) and the "100-person plan" of the Chinese Academy of Sciences.

Surface and Cross-section Morphology of Hydroxyapatite and Hydroxyapatite Composite Coatings Prepared by Vacuum Cold Spraying

Hydroxyapatite-graphene coating enhances osteoblast attachment and osteoblast filopodia tends to extend to graphene sheets

Cosmetic Pouches

Cosmetic Pouches,Travel Barrel Cosmetics Pouch,Waterproof Travel Cosmetic Pouch,Pvc Cosmetic Pouches

Dongguan C.Y. RedApple Industrial Limited , https://www.hpgbags.com