Trademark: Twobiochem/OEM
Specification: 5kg/drum
Origin: China
Trademark: Twobiochem/OEM
Specification: 5kg/drum
Origin: China
Product Name:Supply High Purity  Medical Grade 99% Atosiban /Atosiban Acetate /90779-69-4
Application :White powder
Specification :98%,99%,99.8%
Synonyms::Also known as: Aviptadil Acetate, Vasoactive intestinal octacosapeptide, AN-7541, FT-0659889, I06-1835, 3B3-081674
Description:Atosiban (trade names Tractocile, Antocin, atosiban SUN) is an inhibitor of the hormones oxytocinand vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to haltpremature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. It was developed by Ferring Pharmaceuticalsin Sweden and first reported in the literature in 1985.Originally marketed by Ferring Pharmaceuticals, it is licensed in proprietary and generic forms for the delay of imminent pre-term birth in pregnant adult women.Â
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TESTÂ ITEMS |
STANDARD PRESCRIBE |
RESULTS |
Description |
White or almost white fluffy powder,hygroscopic |
white fluffy powder,hygroscopic |
identification |
The pricipal peak in the chromatogram obtained the test solution is similar in retention time and size to the pricinpal paek in the chromatogram obtained with reference solution(HPLC) |
Confroms |
Specific rotation |
-45.°~ -55° |
-50.5° |
Acetic acid |
≤10.0% |
5.5% |
Water (K.F) |
 ≤6.0% |
4.0% |
Related petides(HPLC) |
Individual impurity≤1.0% |
0.26% |
Total impurities≤2.0% |
0.69% |
Residue organic solvents |
≤0.5% aether
≤0.041%acetonitrile
≤0.06%methylene chloride
≤0.088%N'N-Dimethylformamide
|
0.041%
0.004%
ND
ND
|
Bacterial endotoxin |
<5.0 EU/mg |
<5.0 EU/mg |
Assay |
97.0~103.0%
(anhydrous ,acid-free)
|
99.9% |
Conclusion : |
Comply with the in-house standard |
FUNCTIONS
Atosiban is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra). Atosiban inhibits the oxytocin-mediated release of inositol trisphosphatefrom the myometrial cell membrane.Â
Atosiban is useful in improving the pregnancy outcome of in vitro fertilization-embryo transfer (IVF-ET) in patients with repeated implantation failure (RIF). The pregnancy rate improved from zero to 43.7%.
Â
Product Name:Supply High Purity  Medical Grade 99% Atosiban /Atosiban Acetate /90779-69-4
Application :White powder
Specification :98%,99%,99.8%
Synonyms::Also known as: Aviptadil Acetate, Vasoactive intestinal octacosapeptide, AN-7541, FT-0659889, I06-1835, 3B3-081674
Description:Atosiban (trade names Tractocile, Antocin, atosiban SUN) is an inhibitor of the hormones oxytocinand vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to haltpremature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. It was developed by Ferring Pharmaceuticalsin Sweden and first reported in the literature in 1985.Originally marketed by Ferring Pharmaceuticals, it is licensed in proprietary and generic forms for the delay of imminent pre-term birth in pregnant adult women.Â
Â
TESTÂ ITEMS |
STANDARD PRESCRIBE |
RESULTS |
Description |
White or almost white fluffy powder,hygroscopic |
white fluffy powder,hygroscopic |
identification |
The pricipal peak in the chromatogram obtained the test solution is similar in retention time and size to the pricinpal paek in the chromatogram obtained with reference solution(HPLC) |
Confroms |
Specific rotation |
-45.°~ -55° |
-50.5° |
Acetic acid |
≤10.0% |
5.5% |
Water (K.F) |
 ≤6.0% |
4.0% |
Related petides(HPLC) |
Individual impurity≤1.0% |
0.26% |
Total impurities≤2.0% |
0.69% |
Residue organic solvents |
≤0.5% aether
≤0.041%acetonitrile
≤0.06%methylene chloride
≤0.088%N'N-Dimethylformamide
|
0.041%
0.004%
ND
ND
|
Bacterial endotoxin |
<5.0 EU/mg |
<5.0 EU/mg |
Assay |
97.0~103.0%
(anhydrous ,acid-free)
|
99.9% |
Conclusion : |
Comply with the in-house standard |
FUNCTIONS
Atosiban is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra). Atosiban inhibits the oxytocin-mediated release of inositol trisphosphatefrom the myometrial cell membrane.Â
Atosiban is useful in improving the pregnancy outcome of in vitro fertilization-embryo transfer (IVF-ET) in patients with repeated implantation failure (RIF). The pregnancy rate improved from zero to 43.7%.
Â
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